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Rev. Sharpton To Launch Initiative To Fight Homophobia, HIV/AIDS in Black Community

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Rev. Al Sharpton has said he plans to help launch a grassroots initiative to fight homophobia in the black community, a problem that has "undoubtedly contributed" to the spread of HIV among black people in the U.S., especially black women, the New York Sun reports. Sharpton's initiative is being organized by Marjorie Fields-Harris, executive director of the National Action Network, Sharpton's civil rights organization. The initiative will consist of forums at public schools and churches aimed at educating the black community about HIV/AIDS "and the dangers of homophobia," according to the Sun. Sharpton said he also will launch public service announcements on radio stations with predominantly black audiences and make the issue a key component of his civil rights work in the coming year. "Historically, the black church has been a sanctuary for black people," Phill Wilson, executive director of the Black AIDS Institute, said, adding, "But sadly, black churches have not stepped up to the plate on HIV as they have historically stepped up to the plate on other issues." Wilson added, "We should be celebrating the humanity in all of us, rather than diminishing the humanity in some of us" (Watson, New York Sun, 8/3).

Meth Users Three Times as Likely as Nonusers To Be HIV-Positive, Study Says

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Crystal methamphetamine users are at least three times as likely as nonusers to be HIV-positive, according to a research letter published in the Sept. 2 issue of the medical journal AIDS, the San Francisco Chronicle reports. The study -- which was conducted by researchers from CDC, the University of California-San Francisco and the San Francisco Department of Public Health -- surveyed nearly 3,000 men who have sex with men who tested anonymously for HIV in 2000 and 2001 in San Francisco (Gordon, San Francisco Chronicle, 8/16). Of the 290 participants who reported using crystal meth, HIV incidence was 6.3% annually. However, HIV incidence among 2,701 respondents who said they had not used the drug was 2.1% (Buchacz et al., AIDS, 9/2). Jeffrey Klausner, director of sexually transmitted disease prevention and control for the Department of Public Health and the study's lead author, said it is crucial to combine drug treatment and prevention programs with efforts to curb the spread of HIV and other sexually transmitted diseases. James Dilley, director of the UCSF AIDS Health Project, said crystal meth use "is the newest and most important threat to the HIV epidemic in the United States" (San Francisco Chronicle, 8/16).


HIV-Positive MSM Finding Partners Through 'Sero-Sorting' Might Be Contributing to Decline in HIV Incidence in San Francisco

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Health officials in San Francisco are "scrambling" to explain an apparent decline in annual HIV incidence among the city's men who have sex with men, the New York Times reports (Murphy, New York Times, 8/18). A CDC study released in June found San Francisco's HIV incidence rate among MSM has nearly halved in the last four years. The study, based on a survey of 365 MSM who were tested in the city, found an annual incidence rate of 1.2%, compared with city epidemiologists' previous estimate of 2.2%. The study led the San Francisco Department of Public Health's Office of AIDS to analyze data sets collected by the Stop AIDS Project and surveys of new cases at city clinics, both of which indicated a similar decrease in the number of new HIV cases (Kaiser Daily HIV/AIDS Report, 7/21). Willi McFarland, director of the HIV seroepidemiology unit at the San Francisco Department of Public Health, said, "We interpret this CDC report as good news, and there are some other encouraging trends and results of other studies," adding, "But we definitely do need to corroborate and independently confirm any decrease in HIV incidence by carefully examining other data. We also need to figure out if this is true, then why."

Possible Reasons

Some health officials attribute the decline in incidence to conventional efforts, such as HIV treatment programs, more frequent HIV testing, educational meetings and workshops and harm reduction strategies that work to reduce crystal methamphetamine usage, which is blamed for helping spread the virus. But other experts say that an increase in the number of MSM who know their HIV-positive status and who search for HIV-positive partners on matchmaking Web sites designed specifically for them might be contributing to the decrease in new HIV cases. The dating practice, which is called "sero-sorting," involves men choosing sex partners based on their common HIV serostatus, which refers to the presence of antibodies to a particular infectious agent in the blood, according to the Times. "Studies have shown when people have knowledge of their serostatus, they take that knowledge and use it to protect their partners," Patrick Sullivan, chief of CDC's behavioral and clinical surveillance branch, said, adding, "Sero-sorting is one piece of that whole benefit that arises from people learning their status through HIV testing." Sullivan called the CDC report a "snapshot in time" and noted that directly comparable data will not be available until another survey is conducted in 2007 (Murphy, New York Times, 8/18).

NEW WEB SERVICE HELPS MEDICARE BENEFICIARIES

A new web-based service will help Medicare beneficiaries of limited income and resources gain access to the extra help available to them through the Medicare Modernization Act of 2003. The service, which will also help them enroll in other health care and prescription drug assistance programs, was developed by the Administration on Aging (AoA) with the assistance of the Centers for Medicare & Medicaid Services (CMS) and the National Council on the Aging (NCOA).

"This new resource helps bring together many assistance programs available to seniors who need the most help - and that includes the comprehensive extra help with drug costs that will soon be available for up to one third of Medicare beneficiaries through the new Medicare drug benefit," said Mark B. McClellan, M.D., Ph.D., administrator of the Centers for Medicare & Medicaid Services. "Through this partnership, we have taken another important step forward in our goal of providing better healthcare and more help to America 's seniors."

The new service is a special version of BenefitsCheckUpRx updated for the extra help with Medicare drug coverage. It is available at

http://www.BenefitsCheckUp.org/rx

BenefitsCheckUpRx will help older adults and the advocates who work with them take advantage of the Medicare low-income subsidy, the comprehensive extra help that covers 95 percent of drug costs on average for people with Medicare who have limited means. Applications are available now and altogether, about one in three Medicare beneficiaries are eligible for the extra help. The new service screens beneficiaries for eligibility and then provides a quick link to applying online for the extra help through the Social Security Administration's Web site. At the same time, it helps seniors and those who work with them apply for other needs-based government programs including the Medicare Savings Programs and other federal, state and private programs that can save seniors money.

"AoA, CMS and NCOA share the same vision," said Josefina Carbonell, assistant secretary for Aging at the Department of Health and Human Services, in remarks during the national meeting of the National Association of Area Agencies on Aging today. "We see a national network of community-based organizations using BenefitsCheckUpRx to help people with limited incomes enroll in the new Medicare Prescription Drug coverage and to ultimately enroll in other federal benefits programs."

"Through this unprecedented partnership, we expect to be able to reach and enroll many more seniors in both the extra help available from Medicare and with other needed benefits," said James Firman, Ed.D., NCOA president and CEO. "For NCOA and for BenefitsCheckUp, this is major milestone. Everyone with Medicare who may be eligible for the extra help with drug coverage should enroll as soon as possible, and this new tool will help make that happen."

Using BenefitsCheckUpRx, people with Medicare can get help learning about and applying for the Medicare low-income subsidy if they are eligible, as well as learn about how to enroll in various programs, including state pharmacy assistance programs, private company patient assistance programs, veterans and TRICARE benefits, Medicaid, Medicare Savings Programs (QMB, SLMB, QI), Supplemental Security Income, and the Medicare-approved drug discount cards can be obtained through December 2005. The tool is confidential: no one is required to enter their name, address, phone number, or Social Security number until they enroll.

Next year, Medicare beneficiaries who receive full Medicaid benefits or who are enrolled in a Medicare Savings Program (MSP) will automatically receive the extra help with their prescription drug costs. That extra help provides comprehensive drug coverage with no premiums, no deductibles, very low copays and no gaps in coverage. States have the flexibility in deciding what rules to use when determining eligibility for their Medicare Savings Program beneficiaries, which means that these requirements can vary considerably from state to state. To help clarify the differences among states' eligibility criteria, CMS has information showing how those criteria differ from state to state and how beneficiaries can use that information to determine their eligibility for extra help at

http://www.cms.hhs.gov/medicarereform/states/whatsnew.asp

In addition, the new BenefitsCheckUpRx incorporates state-specific income and asset eligibility requirements into its on-line screening tool.

The NCOA has also created a special organizational version that will provide training and ongoing customer support for Area Agencies on Aging, State Health Insurance Assistance Programs, State Units on Aging, and other local agencies that serve seniors and persons with disabilities.


Medicare rolls out new drug plan

http://sfgate.com/cgi-bin/article.cgi?f=/c/a/2005/08/11/BUGB6E61881.DTL

People enrolled in Medi-Cal, the state-federal insurance program for the poor, will be automatically enrolled in a Medicare prescription drug plan this fall and will have the chance to switch to another plan. Grant, from Senior Action Network, said he thinks that aspect is not well designed.

"The randomly selected plan may or may not cover their medications," he said. "There are 8,000 people in nursing homes in San Francisco covered by Medi-Cal. How many will be able to read the letter, scan the Internet to see if their drugs are covered and their facility pharmacy is part of the plan, and then switch to the right one by Dec. 1 to keep their medications going? That's the big train wreck we see is this whole Medi-Cal thing."


HHS-Sponsored 4parents.gov Web Site for Parents of Teens Contains Inaccurate, Misleading Information, Review Says

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An HHS Web site designed to help parents discuss sexual abstinence with their teenage children contains inaccurate and misleading information about condoms, sexual orientation, dangers associated with oral sex and single-parent households and potentially could lead to riskier behavior among young people or alienation among families, according to medical experts who reviewed the material at the request of Rep. Henry Waxman (D-Calif.), the Washington Post reports (Connolly, Washington Post, 7/14). The Web site -- 4parents.gov -- was developed by HHS' Office of Population Affairs and Administration for Children and Families and includes information on various health topics, statistics, conversation starters and interactive tools and also instructs parents to tell their teenage children to abstain from sex. Earlier this year, 145 advocacy groups -- including the American Civil Liberties Union, Human Rights Campaign, Planned Parenthood Federation of America and the Sexuality Information and Education Council of the United States -- sent a letter to HHS Secretary Mike Leavitt criticizing the Web site for including inaccurate information. HHS in May revised some parts of the site, but some advocacy groups said the changes did not address all of the groups' criticisms (Kaiser Daily Reproductive Health Report, 5/12).

Review Findings

At Waxman's request, three physicians and a child psychologist independently reviewed the Web site (Washington Post, 7/14). Three of the reviewers noted positive aspects of the site, and all four reported problems with the site's accuracy, balance and comprehensiveness, the Los Angeles Times reports. King Holmes, a University of Washington medical professor specializing in infectious diseases, including HIV/AIDS, said a sexually transmitted disease chart included on the site understates condom effectiveness. The chart says condom use "is associated with some decreased risk" of contracting chlamydia, gonorrhea, syphilis and herpes, but Holmes said it should read that condom use is associated with "significantly decreased risk" of transmitting the STDs. He also said the site understates the effectiveness of antiretroviral drugs in prolonging the lives of HIV-positive individuals. John Santelli, chair of the Department of Population and Family Health at the Columbia University Mailman School of Public Health, criticized the Web site for relying on media reports to assert that teens increasingly engage in oral sex, saying there is little evidence that the rates have increased over time. The Web site also says "oral sex is as dangerous in terms of disease as is intercourse," which Santelli said is incorrect (Alonso-Zaldivar, Los Angeles Times, 7/14). The other reviewers -- Richard Pleak, a child psychologist and associate professor of clinical psychiatry at Albert Einstein College of Medicine, and Laurence Steinberg, a psychology professor at Temple University and author of "The Ten Basic Principles of Good Parenting" -- noted inaccuracies in how the site addresses homosexuality and omissions of information about other topics parents of teens might need, such as how to address concerns about alcohol or tobacco use.

Waxman Letter

Waxman on Wednesday sent a letter to Leavitt outlining the reviewers' findings and urging him to remove the Web site from the Internet and "start from scratch" (Sternberg, USA Today, 7/14). He wrote, "The content appears to have been guided by ideology, not a commitment to providing parents and teens reliable information about sex," adding, "A federally funded Web site should present the facts as they are, not as you might wish them to be. It is wrong -- and ultimately self-defeating -- to sacrifice scientific accuracy in an effort to frighten teens and their parents" (Los Angeles Times, 7/14). Waxman in the letter also said the Web site was not created by CDC experts or "any other science-based agency of the federal government" but was produced by the National Physicians Center for Family Resources, which he called an "obscure" group that has "erroneously linked abortion to breast cancer" and criticized NIH for saying condoms are highly effective at preventing STDs (CQ HealthBeat, 7/13). Waxman said Leavitt should overhaul the Web site and "use the best information available from health experts and give advice that's proven to work" (USA Today, 7/14).

HHS Reaction

HHS spokesperson Daniel Morales said the agency had received but not yet reviewed Waxman's letter and could not comment on it. "The purpose of the Web site is to equip parents with the resources they need to talk to their youth about sex and relationships, encourage their teens to remain abstinent from unhealthy risk behaviors and to take an active role in the sexual health of their teens," Morales said. NPCFR Chair John Whiffen said he is open to suggestions for changes and plans to add information on alcohol and tobacco use. However, he defended the site's promotion of sexual abstinence and the failure rates of some contraceptives (Washington Post, 7/14). Alma Golden -- HHS deputy assistant secretary for population affairs, the department that oversaw the project -- said her office previously has heard similar concerns about information on the Web site and plans to correct any mistakes on the site in order to provide accurate information for parents (Los Angeles Times, 7/14).


Ohio Jury Awards $490,000 To Former McDonald's Employee Claiming Company Discriminated Based on HIV-Positive Status

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A Cuyahoga County, Ohio, Common Pleas Court jury on Thursday ruled that fast-food company McDonald's pressured a former employee to resign in 1997 because of his HIV-positive status and awarded the man $490,000, the Akron Beacon Journal reports (Akron Beacon Journal, 7/8). Russell Rich, who had worked at McDonald's for 20 years and was employed as a manager when he resigned, first sued the corporation in October 1998, saying supervisors had altered his duties after he complained about a "hostile work environment." Rich, who has AIDS, in 2001 won a $5 million verdict against McDonald's, but a three-judge panel of the 8th Ohio District Court of Appeals in October 2003 overturned the award, ruling that the company did not receive a fair trial. McDonald's offered to settle out of court for $300,000, but Paige Martin, Rich's attorney, said the offer was inadequate. Judge John Patton, a retired judge from Ohio's 8th District Court of Appeals, began proceedings on a new trial in Cuyahoga County last month (Kaiser Daily HIV/AIDS Report, 6/21).

Reaction, Next Steps

After the ruling on Thursday, Rich said, "With me, it's always been the principle, not really the money, but I was disappointed in the amount [awarded] because my medications cost $145,000 per year." Martin said she will appeal the award amount because she said Patton made errors during the trial. McDonald's said it might appeal the ruling. "We are clearly disappointed with the jury's verdict in this case," McDonald's spokesperson Bill Whitman said, adding, "As we have stated from the beginning of this case, Mr. Rich's allegations are baseless and without merit." Rich said he is hoping McDonald's will create an "AIDS policy" for its employees (Akron Beacon Journal, 7/8).


Pittsburgh Post-Gazette Examines Growing National Concern About HIV/AIDS Among Seniors

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The Pittsburgh Post-Gazette on Tuesday examined the growing national concern about the increase in the number of HIV/AIDS cases among seniors. U.S. seniors often do not practice safe sex because they are not concerned about pregnancy and do not think they are at risk of HIV infection. However, the number of AIDS cases among U.S. residents older than 50 increased fivefold between 1995 and 2003, according to Gina Focareta, communications director for the Pittsburgh AIDS Task Force. Despite the growing prevalence of the disease among this population, there are few prevention programs that target older people, according to the Post-Gazette. In response, the Southwestern Pennsylvania AIDS Planning Coalition and several other groups in the area have begun outreach and prevention programs to educate seniors about the risk of HIV/AIDS (Semuels, Pittsburgh Post-Gazette, 6/28).


California, Federal Government Reach Agreement on Medi-Cal Funding; Deal Would Put More Beneficiaries Into Managed Care (San Francisco Chronicle)

http://cme.kff.org/Key=8028.Cpm.H.D.HqHv4f


CMS Medicare Prescription Drug Formularies To Cover Nearly All HIV/AIDS-Related Medications

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CMS in a document released on Friday said it is requiring Medicare prescription drug plans to cover "all or substantially all" drugs in six categories, including HIV/AIDS-related medications, CQ HealthBeat reports (CQ
HealthBeat, 6/13). Medicare beneficiaries without existing prescription drug coverage will be able to enroll in the program beginning in November, with coverage beginning Jan. 1, 2006. Enrollment will remain open until May 2006, after which time beneficiaries wishing to enroll will have to pay higher fees.
Under the final rules, the average beneficiary enrolling in the prescription drug plan will pay an estimated $35 in monthly premiums, as well as a $250 annual deductible. Medicare will cover 75% of the next $2,000 in prescription drug expenses. After that, beneficiaries will pay full drug expenses until their total annual expenditures reach $5,100. Medicare will cover 95% of drug costs after that point (Kaiser Daily HIV/AIDS Report, 3/15). Health insurance plans cannot use techniques such as prior authorization or step therapy to manage drug costs in the HIV/AIDS category, according to the CMS document. However, insurance plans can require physicians to obtain prior authorization before prescribing the injectable antiretroviral drug Fuzeon, CMS said (CQ HealthBeat, 6/13). North Carolina-based biotechnology firm Trimeris and Swiss drug maker Roche jointly developed Fuzeon, which is in a class of drugs called fusion inhibitors and is designed for HIV/AIDS patients who have failed to respond to other medications. The drug has encountered resistance from doctors and patients because of its high cost -- about $20,000 per patient annually -- and twice daily injection delivery method (Kaiser Daily HIV/AIDS Report, 3/14). Any drugs in the six categories that are approved for marketing after Jan. 1 will be subject to review by a plan's "pharmacy and therapeutics committee" to decide whether they will be covered, the agency said. In addition, CMS said it will revisit the drug formularies for the six categories for 2007 (CQ HealthBeat, 6/13).


Mexico Launches Antihomophobia Campaign in Effort To Encourage More People To Undergo HIV Testing

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The Mexican government has launched an antihomophobia campaign in an effort to encourage more people to undergo HIV testing, the Christian Science Monitor reports. The campaign -- which currently is airing advertisements in 19 cities and will go nationwide this month -- originated with a 2001 constitutional amendment signed by Mexican President Vicente Fox that outlaws discrimination, including sexuality-based bias. Since 2003, federal agencies have been required to provide funding for tolerance campaigns in the country. The government hopes that reducing the stigma around homosexuality will allow more people to receive HIV testing and treatment and help control the spread of the virus in the country. In 2004, the government reported 93,979 HIV/AIDS cases. However, UNAIDS estimates there are about 160,000 HIV-positive people in the country (Campbell, Christian Science Monitor, 6/9).

Washington Post Examines Online Dating Services for People With STDs, Including HIV

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The Washington Post on Tuesday examined online dating services designed specifically for people with sexually transmitted diseases, including HIV/AIDS, hepatitis B, human papillomavirus and herpes. The Web sites -- such as Positive Personals, for HIV-positive individuals, and AfterH, for people with HPV or herpes -- allow members to interact without the concern of how and when to discuss their medical condition. According to Charles Ebel, vice president of health program resources at the American Social Health Association, "[T]hese sites can help break [newly diagnosed individuals] out of their temporary isolation and provide their first step back into the dating world." More than 65 million people in the United States have a viral STD (Booth, Washington Post, 5/10). The complete article is available online.

Temporary Increases in HIV Viral Load Not Indicative of Waning Effectiveness of Antiretroviral Treatment, Study Says

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Sudden increases in the viral loads of HIV-positive people taking antiretroviral drugs usually are harmless, temporary "blips" that do not indicate that the treatment is becoming less effective, according to a study published in the Feb. 16 issue of the Journal of the American Medical Association, Reuters reports (Reuters, 2/15). Dr. Richard Nettles and colleagues at Johns Hopkins University School of Medicine every few days for three to four months between June 2003 and February 2004 collected and analyzed blood samples from 10 HIV-positive people taking antiretroviral drugs whose viral loads had been less than 50 copies per milliliter of blood for at least six months since beginning treatment. Blips -- defined as increases in viral load to 50 or more copies per milliliter without a change in treatment -- were detected in nine of the 10 patients (BBC News, 2/16). According to the researchers, the blips -- which on average lasted less than three days -- had "no connection" to drug resistance except in cases when a patient's viral load increased to 200 or more copies per milliliter or if the increase persisted in repeated tests, Scripps Howard/Long Island Newsday (Scripps Howard/Long Island Newsday, 2/16). Researchers also found no evidence that viral mutations were taking place (Reuters, 2/15). While the study found a "margina[l]" association between blips in viral load and nonadherence to antiretroviral therapy, they did not occur in relation to illness, vaccination or antiretroviral drug concentrations, according to the study. Frequency of blips also was not associated with demographic, clinical or treatment variables, according to the study (Nettles et al., JAMA, 2/16).

Author Comment, Reaction

"These results should provide relief to hundreds of thousands of HIV-positive patients in the United States currently taking drug therapy ... and reassure them their medications have not failed," Dr. Robert Siliciano, JHU professor and senior author of the study, said (Scripps Howard/Long Island Newsday, 2/16).

"Resistance to HIV drugs is a real cause for concern due to the difficulty of adhering to strict drug regimens and the ability of the HIV virus to mutate," Yusef Azad, policy director at the British HIV/AIDS advocacy group National AIDS Trust, said, adding, "However, this research shows that it is important not to jump to hasty conclusions based on slight changes in viral load" (BBC News, 2/16).


Crystal Meth Use Fuels Rise in HIV Cases Among White MSM; 'Down Low' Term Should Apply To All Races, Studies Say

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Crystal methamphetamine use continues to fuel a rising number of HIV cases among white men who have sex with men and the term "on the down low" -- which typically describes men who have sex with both male and female partners but do not mention their male relationships to friends, family members or female partners -- should be applied to all races, not just to black men, according to studies presented Wednesday at CDC's 2005 National HIV Prevention Conference in Atlanta, the Atlanta Journal-Constitution reports (Wahlberg, Atlanta Journal-Constitution, 6/16). Officials from the L.A. Gay & Lesbian Center on Wednesday presented data based on 19,300 HIV tests conducted over four years. Center employees asked MSM if they had used crystal meth since their last HIV test or in the previous two years, whichever was more recent. Data showed almost one in three MSM who tested positive in 2004 said they had used crystal meth, nearly triple the rate of meth use among MSM testing HIV-positive in 2001, center officials said. More than 10% of all MSM tested at the center in 2004 said they had used meth, almost double the rate from 2001. Many experts agree that meth use is a "growing threat" to MSM nationwide because it increases arousal and reduces inhibition, often encouraging people to seek multiple sexual partners, which could put MSM at an increased risk of contracting HIV, the Los Angeles Times reports. Being Alive, a Los Angeles-area coalition of people living with HIV/AIDS, later this month plans to launch a campaign encouraging meth users to get HIV/AIDS education andtreatment (Ornstein, Los Angeles Times, 6/16).

Down Low Study

In addition to black MSM, other races also use the term on the down low, though to a lesser extent, according to a CDC study -- the agency's first on the phenomenon. Researchers surveyed 328 MSM in 12 cities and found that 43% of black men, 26% of Hispanic men and 7% of white men reported being on the down low. About 13% of all MSM surveyed said they had a steady female sexual partner, and about one-third said they considered themselves to be gay. Most of the men reported using condoms during intercourse but not always regularly. The study recommends that the on the down low phrase be expanded to include other races and men who do not have steady female partners. Richard Wolitski, acting chief of prevention research in the CDC Divisions of HIV/AIDS Prevention, agreed, saying it is a myth that all men on the down low fit a specific profile (Atlanta Journal-Constitution, 6/16).

Internet Sex Study

MSM who meet sexual partners over the Internet are more likely to engage in risky sex, compared with MSM who meet partners in other ways, but they also are more likely to do so with people of the same HIV status, according to a study conducted by the
Denver public health department and presented on Wednesday at the conference, Reuters reports. According to data collected from a Denver sexually transmitted disease clinic in 2003 and 2004, 41% of men who met sexual partners over the Internet reported having unprotected anal intercourse with their most recent partner, compared with 31% of men who met partners in bathhouses, 29% who used other public sex venues and 25% of men
who met partners at bars or parties. The study also found that 51% of men who met sexual partners over the Internet chose someone with the same HIV status as themselves, compared with about 20% of men who met partners in bathhouses. Two other studies presented at the conference showed that many HIV-positive MSM are choosing sex partners based on their viral load level, a finding that prompted warnings from health
officials, who said HIV, as well as other STDs, can still be transmitted when viral levels are low (Simao, Reuters, 6/15).

New York Times Profiles Young Adults, Pre-Teens Who Were Born HIV-Positive, Examines Their Unique Challenges

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The New York Times on Sunday profiled several young adults, teenagers and pre-teens who were born HIV-positive, the difficulties their families face about how and when to educate them about HIV/AIDS and the difficulties they face coping with a lifetime of disease. As antiretroviral treatment has improved, a "generation of young people whose unexpected maturation is both a miracle and an extraordinary challenge" has emerged, the Times reports. However, because HIV-positive people often face stigma in the United States and because talking about HIV often involves discussions of unprotected sex or other topics usually reserved for older children or adults, some parents decide to wait until their HIV-positive children are teenagers before telling them they are HIV-positive. In 1990, about 2,000 children nationwide were born HIV-positive. Because drugs are available that drastically reduce the risk of transmitting HIV during pregnancy or delivery, only about 200 HIV-positive infants are born annually in the United States today (Dee, New York Times, 6/26).

Los Angeles Times Examines Lingering Doubts About Rare, Drug-Resistant HIV Strain in New York City

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The Los Angeles Times on Sunday examined HIV/AIDS experts' doubts about the importance of a rare, highly drug-resistant HIV strain detected in a New York City man in February and the decision to publicize the case widely (Piller, Los Angeles Times, 6/5). Officials from the New York City Department of Health and Mental Hygiene on Feb. 11 announced they had detected the HIV strain, which is resistant to most antiretroviral drugs and possibly causes a rapid onset of AIDS. The city health department issued an alert to physicians, hospitals and medical providers asking them to test all
HIV-positive patients for evidence of the strain. The strain's combination of highly drug-resistant HIV and rapid progression to AIDS had not been identified before (Kaiser Daily HIV/AIDS Report, 3/30). Some HIV/AIDS experts have questioned the rationale behind the alert, saying it was "scientifically naïve and needlessly alarmist," particularly because no super-strain emerged, the patient in question is responding to antiretroviral treatment and no other related cases have been found, the Times reports. Although the alert emphasized that limited conclusions could be drawn from just one case, "the event seemed suffused with the subtext that this could be a turning point in the epidemic," according to the Times. However, other experts and advocates think the announcement "offered a rare megaphone to wake people up" at a time when the HIV/AIDS epidemic "has lost some of its urgency," the Times reports (Los Angeles Times, 6/5).


Sermons at Black Churches Condemning Men Who Have Sex With Men Contribute to Spread of HIV, Editorial Says

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"[H]ell-and-brimstone" sermons "condemning" sexual relations with a partner of the same gender "remain the norm in many black churches" and are pushing men who have sex with men "underground" and contributing to the spread of HIV, a Los Angeles Times editorial says. HIV predominately has been spread by MSM in the United States, and many black MSM do not identify themselves as gay and often transmit the disease to women, according to the Times. Sermons condemning MSM do not "dete[r] gay relationships" and can create "an atmosphere of secrecy and shame" that "discourages men from getting tested for HIV," the editorial says. Blacks account for 51% of new HIV cases -- including 69% of new cases among women -- but black churches have been "slo[w]" to "join in the fight against AIDS," the editorial says. Although black church leaders can "play a positive role" in lobbying the Bush administration for the provision of antiretroviral drugs and condoms to fight HIV/AIDS in Africa, "they could and should play a greater role" in fighting the "enormous" needs of their local communities, the editorial says (Los Angeles Times, 6/3).

Senate Special Committee on Aging Hears Testimony on Growing Number of HIV-Positive People Older Than 50

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Dr. Robert Janssen, director of CDC's Division of HIV/AIDS Prevention on Thursday during a Senate Special Committee on Aging hearing, told lawmakers that the number of HIV-positive people older than 50 is "growing sharply," the AP/KPVI-TV reports (AP/KPVI-TV, 5/12). "One of the challenges in people 50 and older is the mistaken belief that they're not at risk," Janssen said, adding that many older people do not see the "importance of using condoms," especially older women who are not concerned about becoming pregnant. A lack of awareness about HIV/AIDS among older people and stereotypes associated with this group -- such as decreased sexual activity – also might contribute to the spread of the disease, according to committee Chair Gordon Smith (R-Ore.) (Zwillich, WebMD Medical News, 5/13). Jeanine Reilly, executive director of the Broadway House for Continuing Care in Newark, N.J., at the hearing said some researchers refer to nursing homes as the "new breeding ground for AIDS," adding that "simple" HIV/AIDS educational material geared toward an older population is needed, the AP/KPVI-TV reports. She said that older HIV/AIDS patients also require different standards of care (AP/KPVI-TV, 5/12). Smith said he likely will include provisions for improved HIV/AIDS education for older people in the Ryan White CARE Act, which Congress is expected to reauthorize later this year. About 28% of HIV/AIDS patients in the United States are older than 50, and that figure could increase to half of all U.S. patients by 2015, Smith said. According to CDC data from 32 states, the number of HIV-positive people older than 50 increased from 40,000 in 2000 to more than 67,000 in 2003 (WebMD Medical News, 5/13).

Mixing Food and Medications

A recent article, "When food makes medicine kill, not cure" (from The Guardian at: http://www.guardian.co.uk/ ) compliments several articles previously published in the HIV ReSource Review http://www.hivresources.com/Contents.html and the HIV Nutrition Update http://www.hivresources.com/3YrHNUp.html . The article points out how vital it is for health care workers, especially doctor's, to be aware of what patients consume along with their medications.

HIV ReSources has published several articles over the past few years about the risk of medication interactions between foods, beverages, botanicals and other dietary supplements. For extensive information on food-drug interactions, readers may visit the Food Medication Interactions web site http://www.foodmedinteractions.com or telephone 800-746-2324. The grapefruit-juice drug interaction web site http://www.powernetdesign.com/grapefruit is helpful for those taking medications that may interact with grapefruit. For extensive information about herb-drug interactions visit the Herb-Drug Interaction Handbook web site http://www.herbdrug.org .

RECENT RELEASES

Campaign To End AIDS Launches Web Site; GBC Appointed NewGlobal Fund Private-Sector 'Focal Point'; YouthNet Releases InfoNet No. 14

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* EndAIDSNow.org: The new nationwide grassroots organization Campaign to End AIDS, which comprises HIV-positive people and advocates, has launched this new Web site. The site includes policy and platform materials, advocacy and fundraising materials and information on cross-country caravans the campaignis planning for the fall (Campaign to End AIDS release, 5/4).

* "Global Business Coalition on HIV/AIDS Appointed Private-Sector 'Focal Point' for the Global Fund To Fight AIDS, Tuberculosis and Malaria Board of Directors": GBC -- which will replace the World Economic Forum as the focal point to the Global Fund -- is increasing its staff capacity and will organize a strategic planning process later this year to develop recommendations for the involvement of corporations with the Global Fund (GBC release, 5/3).

* Youth InfoNet, YouthNet, Family Health International: YouthNet has released Youth InfoNet No. 14, which includes summaries of 15 recently released program resources and seven publications in peer-reviewed journals on youth HIV prevention and reproductive health (FHI release, 5/4).

Many Young, HIV-Positive MSM Unaware of HIV Status, Regular Testing Needed, Study Says

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Many young, HIV-positive men who have sex with men are unaware of their HIV status, according to a study published in the April 15 issue of the Journal of Acquired Immune Deficiency Syndromes, Reuters Health reports. CDC epidemiologist Duncan MacKellar and colleagues studied more than 5,600 men ages 15 to 29 recruited from bars, parks, cafes, stores and other venues in six U.S. cities between 1994 and 2000. The researchers surveyed each of the men about their sexual behavior, perceived HIV risk and HIV testing history and collected blood samples for HIV testing (Norton, Reuters Health, 4/26). Approximately 10% of the men tested positive for HIV, and 77% were unaware of their status, according to the study. Of the 439 men who were unaware of their HIV-positive status, 59% had indicated that they thought they were at low risk for contracting HIV and 51% reported having unprotected anal sex with another man during the previous six months (AFP/Yahoo! News, 4/26). More than half of the men with unrecognized HIV had not been tested in the previous year (MacKellar et al., Journal of Acquired Immune Deficiency Syndromes, 4/15).

Recommendations

The researchers said that the findings are "probably not reflective" of the larger MSM population in the United States because of the study's recruiting method, Reuters Health reports. However, MacKellar said the study "underscores the urgency" of increased HIV testing among MSM. He said limited access to health care services and a fear of testing positive might be reasons for the lack of regular testing observed in the study. The researchers suggested expanding HIV testing services at clubs and bars in order to reach more men who are unaware of their HIV-positive status. MacKellar also said it is important for physicians to recommend routine HIV testing for patients who have an increased risk of contracting the virus (Reuters Health, 4/26).

Crystal Meth Use Can Increase High-Risk Sexual Activity, Lead To Increase in Number of HIV/AIDS Cases, Study Says

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Crystal methamphetamine use can "spark high-risk sex" and might have contributed to a recent increase in the number of new HIV/AIDS cases reported in South Florida, according to a study published in the March issue of AIDS and Behavior, the South Florida Sun-Sentinel reports. Steven Kurtz, a researcher at the University of Delaware's Center for Drug and Alcohol Studies in Coral Gables, Fla., and colleagues interviewed 15 crystal meth users ages 33 to 50 in Miami Beach and Wilton Manors, Fla., to examine the motivations and consequences of crystal meth use among men who have sex with men. The researchers found that crystal meth can lower inhibitions and create "artificial feelings of intimacy" and that the men interviewed participated in "weekend-long parties that included unprotected sex among multiple partners," according to the Sun-Sentinel. Although the findings reflect those of similar studies, Kurtz said that because the study population was small, the findings cannot be applied generally to MSM. However, the study shows that crystal meth can play a "big role" in the rising number of HIV cases among MSM, especially those who feel "ostracized from mainstream society," Kurtz said, according to the Sun-Sentinel.

"Anecdotally, everyone knows this is going on," Kevin Garrity, executive director of the South Beach AIDS Project, said, adding, "This gives us the scientific proof of the hypersexuality that crystal meth can cause" (LaMendola, South Florida Sun-Sentinel, 4/19).

Electronic Listservs

The "FDA HIV/AIDS electronic list serve" http://www.fda.gov/oashi/aids/listserve/archive.html relays important information about HIV/AIDS-related products and issues, including product approvals, significant labeling changes, safety warnings, notices of upcoming public meetings and alerts to proposed regulatory guidance's for comment. Excerpts from a recent FDA Public Health Advisory for Nevirapine (Viramune) are below. To subscribe to this electronic list visit:

http://list.nih.gov/cgi-bin/wa?SUBED1=fda-hiv-aids&A=1 .

Gay Community Must Address Self-Esteem, Depression Issues That Contribute to Crystal Meth Problem, Opinion Piece Says

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A "second revolution must occur within the gay community" in which men and women "'come out' concerning the issues of low self-esteem and depression that are prevalent" in the community and that contribute to crystal methamphetamine use among men who have sex with men, Allen Reese, CEO of Desert AIDS Project, writes in a Palm Springs Desert Sun opinion piece. According to Perry Halkitis, a New York University psychologist, "isolation and low self-esteem" are "root cause[s]" of crystal meth use among many MSM, especially among those who are HIV-positive, Reese says. Mental health problems create a "really vicious cycle" of HIV/AIDS, crystal meth use and depression, according to Halkitis, Reese writes. In-depth studies of depression among gay men and women are needed, and the Desert AIDS Project is "committed" to addressing the issue "in the months and years ahead," according to Reese. If we do not "seek out the root causes of rampant substance abuse, there is little hope for us to have any impact on reducing the use of these drugs within a gay population that is highly vulnerable to acquiring HIV," Reese concludes (Reese, Palm Springs Desert Sun, 4/10).

Consumer Reports Magazine Rates Durex Condoms Best, Planned Parenthood Condoms Worst in Performance Review

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The not-for-profit group Consumers Union on Tuesday released a
report published in the February issue of its Consumer Reports
magazine on 17 contraceptive methods, including top U.S. brands
of condoms that underwent "vigorous testing," Reuters reports.
The group used "standardized tests" -- including filling condoms
with air -- to rate the products it examined, according to
Reuters. Durex Extra Sensitive Lubricated Latex scored the
highest marks on strength and reliability, followed by Durex
Performax Lubricated, Lifestyles Classic Collection Ultra
Sensitive Lubricated and TheyFit Lubricated (Fox, Reuters, 1/4).
Planned Parenthood Federation of America's Honeydew and Assorted
Colors condoms scored the worst of the 23 condoms tested. The
Honeydew condom, which scored "poor" ratings in strength and
reliability, has since been redesigned, according to Long Island
Newsday. The Assorted Colors condoms received "poor" marks for
strength but "excellent" marks for reliability, according to
Newsday. Planned Parenthood has resubmitted the Honeydew and
Assorted Colors condoms -- as well as its Lollipop condom, which
was ranked 14th -- for independent testing, and the condoms
received "excellent results," according to Karen Pearl,
president and CEO of Planned Parenthood of Nassau County in New
York. Pearl "criticized" Consumers Union for performing only
air-inflation tests, which she said favors thinner condoms,
according to Newsday. However, Geoffry Martin, Consumers Union's
director of consumer sciences, said that other tests, such as
measuring water leakage, are not as useful, adding, "We have
found that the air-bursting, air-pressure test is the one that
will distinguish the truly strong from those that are less
strong" (Phan, Long Island Newsday, 1/5).

Comparing Contraception

Consumer Reports also included a "Guide to Contraceptives,"
which discusses and charts 16 other contraceptive choices,
including birth control pills, intrauterine devices and
vasectomy (Consumer Reports, February 2005). The report says
that IUDs, oral contraceptives and emergency contraception have
become "safer than in previous years," according to Reuters.
However, Consumers Union said in a statement that "[c]ondoms
remain the only family planning and pregnancy prevention method
that can help prevent sexually transmitted diseases, including
HIV, which causes AIDS" (Reuters, 1/4).





New YouthLens Publications on HIV/AIDS, Reproductive Health
Issues Released


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* YouthLens, YouthNet, Family Health International: YouthNet has
released two new four-page research briefs on HIV/AIDS- and
reproductive health-related issues aimed at young people ages 10
to 24. YouthLens No. 13, titled "HIV-Infected Youth," addresses
the medical, psychological and social supports that HIV-positive
young people need but often do not receive. YouthLens No. 14,
titled "New Resources on Youth Reproductive Health and HIV
Prevention, 2002-2004," provides Web links to major reports and
resources on youth reproductive health and HIV prevention
published between 2002 and 2004. The briefs are available in
English, Spanish and French (FHI release, 2/4).


HIV Testing Should Be Part of Routine Medical Care; Early
Detection Can Lengthen Lifespan, Prevent Spread, Studies Suggest


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Voluntary HIV testing should be a routine part of medical care
in the United States, and early detection of the disease could
add more than a year to the lifespan of HIV-positive patients at
a cost comparable to other common screenings, including those
for high blood pressure or breast cancer, according to two
independent, federally funded studies published in the Feb. 10
issue of the New England Journal of Medicine, the Baltimore Sun
reports (Niedowski, Baltimore Sun, 2/10). Since the 1980s when
the HIV/AIDS epidemic began in the United States, health
officials have recommended routine HIV testing only for people
living in large cities with high HIV/AIDS prevalence rates or
people in high-risk groups, such as injection drug users or men
who have sex with men, according to the AP/New York Times.
However, the studies suggest that the benefits of routine HIV
testing, including a reduction in the number of new HIV
infections and early treatment for HIV-positive patients, would
outweigh the costs, the AP/Times reports. Health officials
believe that about 30% of the 950,000 HIV-positive people living
in the United States do not know they are infected (AP/New York
Times, 2/10). Dr. Samuel Bozzette of RAND and the University of
California-San Diego, who wrote an accompanying NEJM editorial,
said that although 40% of U.S. residents had undergone HIV
testing by the end of 2002, 40% of those diagnosed HIV-positive
had not been tested until they showed symptoms of AIDS,
according to the Los Angeles Times (Maugh, Los Angeles Times,
2/10).

First Study

Dr. David Paltiel of the department of epidemiology and public
health at Yale University School of Medicine and colleagues from
Harvard University created a computer model to compare routine,
voluntary HIV testing with current testing practices in three
hypothetical populations. The populations included a "high-risk"
group with a 3% prevalence of undiagnosed HIV infection and 1.2%
annual incidence; a "CDC threshold" group with a 1% prevalence
of undiagnosed HIV infection and 0.12% annual incidence; and a
"U.S. general" population group with a 0.1% prevalence of
undiagnosed HIV infection and 0.01% annual incidence. The
researchers then examined quality-adjusted survival, cost and
cost-effectiveness of testing. The researchers found that the
addition of a one-time HIV test for the high-risk group resulted
in earlier diagnosis and an improved average survival time. The
researchers calculated that the cost-effectiveness of a one-time
HIV test for high-risk populations was $36,000 per
quality-adjusted life-year gained. The cost-effectiveness of a
test every five years was $50,000 per quality-adjusted life-year
gained, and testing every three years cost $63,000 per
quality-adjusted life-year gained. For the CDC threshold
population, the researchers calculated that the
cost-effectiveness of a one-time test was $38,000 per
quality-adjusted life-year gained. Testing every five years cost
$71,000 per quality-adjusted life-year gained, and testing every
three years cost $85,000 per quality-adjusted life-year gained.
In the U.S. general population group, a one-time screening cost
$113,000 per quality-adjusted life-year gained. The researchers
concluded that in all but the "lowest-risk" populations,
routine, voluntary HIV testing every three to five years is
"justified on both clinical and cost-effectiveness grounds." The
researchers added that one-time testing for the general
population might be cost-effective (Paltiel et al., New England
Journal of Medicine, 2/10).

Second Study

Dr. Douglas Owens, senior investigator at the Veterans
Administration Palo Alto Medical Center and associate professor
of medicine at Stanford University, and colleagues from Duke
University developed a Markov model of costs, quality of life
and survival associated with a routine, voluntary HIV testing
program and compared the model with current testing practices.
The researchers examined the cost-effectiveness of one-time
screening both with and without considering the benefits to the
sexual partners of the people who underwent testing. When
considering only the benefits to an identified patient, the
researchers found that with a 1% prevalence of unidentified HIV
infection, a one-time screening program increased life
expectancy by 3.92 days at a cost of $333 when compared with
current testing practices, for a cost-effectiveness ratio of
$41,736 per quality-adjusted life-year. Taking into
consideration the costs and benefits to partners, one-time
screening would cost $194 more than current practices and
increase life expectancy by 5.48 days, resulting in an
incremental cost-effectiveness ratio of $15,078 per
quality-adjusted life-year. Including costs and benefits to
sexual partners, the prevalence of unidentified HIV infection in
a population can be as low as 0.05% before testing costs $50,000
per quality-adjusted life-year, according to the study. Testing
every five years cost $57,138 per quality-adjusted life-year but
would be "more attractive" than one-time testing in populations
with a high incidence of HIV infection. The researchers
concluded that routine, voluntary testing -- even among
relatively low-prevalence populations -- is as cost-effective as
"commonly accepted interventions, and such programs should be
expanded" (Owens et al., New England Journal of Medicine, 2/10).
The researchers concluded that one-time testing of the general
population could reduce the annual U.S. HIV transmission rate by
20% and that HIV-positive people diagnosed through such testing
could gain an average of 1.5 years of life, according to the
AP/Houston Chronicle (Johnson, AP/Houston Chronicle, 2/9).

Reaction

Paltiel said that what makes routine, voluntary testing in the
general population "so imperative is that there are 900,000
people infected with HIV in this country, and 280,000 don't know
it," adding, "They're unable to get access to lifesaving
therapy, and we are unable to counsel them to prevent
transmission of this disease. That's a huge failure of the
public health process" (Sternberg, USA Today, 2/10). Rochelle
Walenksy, an infectious disease specialist at Massachusetts
General Hospital and a co-author of the first study, said, "The
whole message that we're really trying to convey is: It's not
about, 'Who should we test?' It's about, 'We should test
everyone'" (Baltimore Sun, 2/10). Bozzette in his editorial
wrote, "Given the availability of effective therapy and
preventive measures, it is possible to improve care and perhaps
influence the course of the epidemic through widespread,
effective and cost-effective screening" (AP/Houston Chronicle,
2/9). According to Paltiel, CDC should be "much more aggressive"
about implementing HIV testing for the general population, the
Atlanta Journal-Constitution reports (Wahlberg, Atlanta
Journal-Constitution, 2/10). Robert Janssen, director of
HIV/AIDS prevention at CDC, said that the agency over the next
two years will re-evaluate its testing guidelines and consider
the results of the two studies and the availability of rapid HIV
tests, according to the AP/Times (AP/New York Times, 2/10).
"Should we consider testing the general population?" Janssen
asked, adding, "It's an important question. But there are
barriers." Janssen said the most significant barrier to testing
the general population is that many insurance companies do not
pay for routine HIV testing, according to the
Journal-Constitution. In addition, some doctors say they are
"too rushed" to test patients for HIV, and some people avoid
getting tested because of stigma attached to the disease, the
Journal-Constitution reports (Atlanta Journal-Constitution,
2/10).


Temporary Increases in HIV Viral Load Not Indicative of
Waning Effectiveness of Antiretroviral Treatment, Study Says


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Sudden increases in the viral loads of HIV-positive people
taking antiretroviral drugs usually are harmless, temporary
"blips" that do not indicate that the treatment is becoming less
effective, according to a study published in the Feb. 16 issue
of the Journal of the American Medical Association, Reuters
reports (Reuters, 2/15). Dr. Richard Nettles and colleagues at
Johns Hopkins University School of Medicine every few days for
three to four months between June 2003 and February 2004
collected and analyzed blood samples from 10 HIV-positive people
taking antiretroviral drugs whose viral loads had been less than
50 copies per milliliter of blood for at least six months since
beginning treatment. Blips -- defined as increases in viral load
to 50 or more copies per milliliter without a change in
treatment -- were detected in nine of the 10 patients (BBC News,
2/16). According to the researchers, the blips -- which on
average lasted less than three days -- had "no connection" to
drug resistance except in cases when a patient's viral load
increased to 200 or more copies per milliliter or if the
increase persisted in repeated tests, Scripps Howard/Long Island
Newsday (Scripps Howard/Long Island Newsday, 2/16). Researchers
also found no evidence that viral mutations were taking place
(Reuters, 2/15). While the study found a "margina[l]"
association between blips in viral load and nonadherence to
antiretroviral therapy, they did not occur in relation to
illness, vaccination or antiretroviral drug concentrations,
according to the study. Frequency of blips also was not
associated with demographic, clinical or treatment variables,
according to the study (Nettles et al., JAMA, 2/16).

Author Comment, Reaction

"These results should provide relief to hundreds of thousands of
HIV-positive patients in the United States currently taking drug
therapy ... and reassure them their medications have not
failed," Dr. Robert Siliciano, JHU professor and senior author
of the study, said (Scripps Howard/Long Island Newsday, 2/16).
"Resistance to HIV drugs is a real cause for concern due to the
difficulty of adhering to strict drug regimens and the ability
of the HIV virus to mutate," Yusef Azad, policy director at the
British HIV/AIDS advocacy group National AIDS Trust, said,
adding, "However, this research shows that it is important not
to jump to hasty conclusions based on slight changes in viral
load" (BBC News, 2/16).

Gay Community Must Address Self-Esteem, Depression Issues
That Contribute to Crystal Meth Problem, Opinion Piece Says


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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=29322

A "second revolution must occur within the gay community" in
which men and women "'come out' concerning the issues of low
self-esteem and depression that are prevalent" in the community
and that contribute to crystal methamphetamine use among men who
have sex with men, Allen Reese, CEO of Desert AIDS Project,
writes in a Palm Springs Desert Sun opinion piece. According to
Perry Halkitis, a New York University psychologist, "isolation
and low self-esteem" are "root cause[s]" of crystal meth use
among many MSM, especially among those who are HIV-positive,
Reese says. Mental health problems create a "really vicious
cycle" of HIV/AIDS, crystal meth use and depression, according
to Halkitis, Reese writes. In-depth studies of depression among
gay men and women are needed, and the Desert AIDS Project is
"committed" to addressing the issue "in the months and years
ahead," according to Reese. If we do not "seek out the root
causes of rampant substance abuse, there is little hope for us
to have any impact on reducing the use of these drugs within a
gay population that is highly vulnerable to acquiring HIV,"
Reese concludes (Reese, Palm Springs Desert Sun, 4/10).


Crystal Meth Use Can Increase High-Risk Sexual Activity, Lead
To Increase in Number of HIV/AIDS Cases, Study Says


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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=29469

Crystal methamphetamine use can "spark high-risk sex" and might
have contributed to a recent increase in the number of new
HIV/AIDS cases reported in South Florida, according to a study
published in the March issue of AIDS and Behavior, the South
Florida Sun-Sentinel reports. Steven Kurtz, a researcher at the
University of Delaware's Center for Drug and Alcohol Studies in
Coral Gables, Fla., and colleagues interviewed 15 crystal meth
users ages 33 to 50 in Miami Beach and Wilton Manors, Fla., to
examine the motivations and consequences of crystal meth use
among men who have sex with men. The researchers found that
crystal meth can lower inhibitions and create "artificial
feelings of intimacy" and that the men interviewed participated
in "weekend-long parties that included unprotected sex among
multiple partners," according to the Sun-Sentinel. Although the
findings reflect those of similar studies, Kurtz said that
because the study population was small, the findings cannot be
applied generally to MSM. However, the study shows that crystal
meth can play a "big role" in the rising number of HIV cases
among MSM, especially those who feel "ostracized from mainstream
society," Kurtz said, according to the Sun-Sentinel.
"Anecdotally, everyone knows this is going on," Kevin Garrity,
executive director of the South Beach AIDS Project, said,
adding, "This gives us the scientific proof of the
hypersexuality that crystal meth can cause" (LaMendola, South
Florida Sun-Sentinel, 4/19).

FDA List Serve: Atazanavir with or without Ritonavir
Should not be Coadministered with Proton Pump
Inhibitors

December 20, 2004

Bristol-Meyers Squibb has issued a Dear Healthcare
Provider letter regarding important new
pharmacokinetic data concerning the coadministration
of REYATAZ (atazanavir) and Norvir (ritonavir) with
Prilosec (omeprazole). Omeprazole is a proton-pump
inhibitor (PPI) for the treatment of acid-related
diseases that works by suppressing gastric acid
secretion.

The following observations were made from a
randomized, open-label, multiple-dose drug interaction
study.
A 76% reduction in atazanavir area under the
concentration-time curve (AUC) and a 78% reduction in
atazanavir trough plasma concentration (Cmin) were
observed when REYATAZ/ritonavir 300/100 mg was
coadministered with omeprazole 40 mg.

Based on the study results:

DO NOT COADMINISTER REYATAZ OR REYATAZ/ritonavir with omeprazole due to the reduction in atazanavir exposure
levels. This recommendation is consistent with the
current REYATAZ U.S. Package Insert.

It is not known whether the over-the-counter dose of
omeprazole (20 mg once daily) would produce similar
results; therefore, coadministration is not
recommended.

Increasing the REYATAZ/ritonavir dose to 400/100 mg in
combination with omeprazole DID NOT result in REYATAZ
exposures comparable to those observed with a regimen
of REYATAZ/ritonavir 300/100 mg without omeprazole.

Simultaneous administration of 8 ounces of cola given
in an effort to decrease (acidify) gastric pH did not
appear to affect this reduction.

Investigations regarding the potential drug
interaction between REYATAZ (atazanavir sulfate) and
H2-Receptor antagonists (another type of gastric
medication) when coadministered are ongoing. Until
data are available, clinicians should note the
following statements from the REYATAZ Package Insert:
"Reduced plasma concentrations of atazanavir are expected if H2-receptor antagonists are administered
with REYATAZ (atazanavir sulfate). This may result in
loss of therapeutic effect and development of
resistance. To lessen the effect of H2 -receptor
antagonists on atazanavir exposure, it is recommended
that an H2-receptor antagonist and REYATAZ be
administered as far apart as possible, preferably 12
hours apart."


 

Federally Funded Abstinence-Only Sex Ed Programs Present 'False' Information on HIV, Other Topics, Report Says

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Federally funded abstinence-only sex education programs present "false and misleading information," according to a report released on Wednesday by Rep. Henry Waxman (D-Calif.), the Washington Times reports (Wetzstein, Washington Times, 12/2).


Several million children ages nine to 18 have participated in the more than 100 federally funded abstinence-only sex education programs since 1999, when such programs began, the Washington Post reports (Connolly, Washington Post, 12/2). Congress earlier this month approved a $388 billion omnibus spending measure (HR4818) for fiscal year 2005 that includes about $168 million for abstinence education programs (Kaiser Daily Reproductive Health Report, 11/29). In FY 2001, about half that amount was allocated for abstinence-only sex education, according to the Times (Washington Times, 12/2).

Findings

Waxman's staff reviewed 13 of the most commonly used abstinence-only sex education curricula in the United States and found that 11 of the programs -- which are used by 69 organizations in 25 states -- contain "unproved claims, subjective conclusions or outright falsehoods regarding reproductive health, gender traits and when life begins," the Post reports. According to the report, some of the claims made by the programs include: that a fetus at 43 days gestation is a "thinking person," that a boy or man can impregnate a woman or girl by touching her genitals, that women who undergo abortion are "more prone to suicide," that 10% of women who undergo abortion become sterile, that 50% of gay male teenagers are HIV-positive, that HIV can be spread through sweat and tears and that condoms fail to prevent sexually transmitted diseases 31% of the time when used during heterosexual intercourse, according to the report, the Post reports. According to the report, a 2001 obstetrics textbook says that fertility is not affected by elective abortion. The statement about gay teenagers might be a misinterpretation of CDC data that found that 59% of HIV-positive boys ages 13 to 19 contracted the virus through unprotected sex with a male, according to the Post. In addition, condoms, when used properly, are more than 97% effective in preventing pregnancy and STDs, including HIV, according to federal research, the Post reports.

Abstinence-Only Opponents

Waxman, a proponent of comprehensive sex education, said that abstinence-only programs make students unprepared to protect against pregnancy or STDs if they become sexually active, the Post reports. "I have no objection talking about abstinence as a surefire way to prevent unwanted pregnancy and sexually transmitted diseases," Waxman said, adding, "I don't think we ought to lie to our children about science. Something is seriously wrong when federal tax dollars are being used to mislead kids about basic health facts." Bill Smith, vice president of public policy at the Sexuality Information and Education Council of the United States, called for closer monitoring of "shame-based, fear-based, medically inaccurate messages" that are promoted in abstinence-only programs (Washington Post, 12/2). Gloria Feldt, president of Planned Parenthood Federation of America, said, "Rep. Waxman's study proves what other research has already revealed -- that abstinence-only programs are ineffective and harmful to young people" (PPFA release, 12/1). Laura Murphy, director of the ACLU Washington Legislative Office, said, "For years, lawmakers have increased spending on abstinence-only programs without clear evidence that they are effective at preventing unplanned pregnancies or sexually transmitted infections, including HIV." She added that the report "demonstrates that public money is being misspent at the expense of our children's health. It should serve as a serious wake-up call to lawmakers" (ACLU release, 12/1).

Abstinence-Only Supporters

However, Dr. Alma Golden, deputy assistant secretary for population affairs at HHS, said that Waxman's report took statements in the abstinence-only programs "out of context" to show them in the "worst possible light," according to the AP/Las Vegas Sun. "These issues have been raised before and discredited," Golden said, adding, "One thing is very clear for our children, abstaining from sex is the most effective means of preventing the sexual transmission of HIV, STDs and preventing pregnancy" (Sherman, AP/Las Vegas Sun, 12/1). Libby Gray, director of Project Reality -- which produces the abstinence-only programs "Game Plan" and "Navigator" -- said, "The information presented in [the programs] is medically accurate, and all information presented is from data compiled by national sources such as CDC, NIH and the American Social Health Association," adding, "These curricula have been reviewed by physicians and public health professionals and have been found to be statistically and medically accurate" (Washington Times,
12/2). Joe McIlhaney, who runs the Medical Institute for Sexual Health, which developed many of the curricula surveyed, said he is "saddened" that Waxman decided to "'blast' well-intentioned abstinence educators" even though abstinence-only education supporters and opponents agree on many things (Washington Post,
12/2).

"High Levels" of Bacteria Found in Bottled Mineral Water: Study

By Megan Rauscher

NEW YORK (Reuters Health) Nov 01 - Bottled mineral water, generally considered more pure than tap water, is often contaminated with bacteria and fungi, a researcher warned today in a report to the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), a meeting of the American Society for Microbiology.

"Hospital water is increasingly accepted as a source for pathogens," Dr. Rocus R. Klont from University Medical Center Nijmegen, the Netherlands, told Reuters Health. "Immunocompromised patients often receive bottled mineral water under the assumption that it is safer than tap water."

To determine the risk of infection from bottled water, Dr. Klont and colleagues look for bacterial and fungal contamination in 68 commercial mineral waters, one tap water, and one water sample from a natural well from nine European and seven non-European countries.

"We found high levels of bacterial contamination in commercially bottled mineral water," Dr. Klont told Reuters Health.

Overall 40% of all samples showed evidence of contamination with either bacteria (37%) or fungi (4%). Bacteria grew from 21 samples, including cultures of 8 coagulase-negative staphylococci, 10 gram-negative nonfermenters and 9 gram-positive rods.

Legionella DNA was detected in six samples and Legionella antigen in six others. Molds were detected in three samples.

"These findings indicate that the general perception that bottled water is safe and clean is not true," Dr. Klont noted in comments to Reuters Health.

"The risk of disease to healthy individuals may be limited, but immunocompromised patients are generally more susceptible to infection and therefore might be at higher risk of becoming infected," he added.

Atlanta Journal-Constitution Examines HIV/AIDS Knowledge of
Women Over Age 50


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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=26676

The Atlanta Journal-Constitution on Wednesday examined the
HIV/AIDS knowledge of women over age 50, who are "extremely
naive" about how the virus is transmitted. According to a study
conducted by researchers at Emory University, about half of the
women surveyed believed that male vasectomy or diaphragms
provide some protection against HIV. In addition, only 13% knew
that condoms were very effective in preventing transmission of
the virus, according to the Journal-Constitution. The study
results were "a little scary," Lisa Bernstein, an assistant
professor of medicine at Emory's School of Medicine and lead
author of the study, said, adding, "These women do not realize
they are at risk. And there is a major knowledge deficit."
However, Kim Anderson, executive director of AID Atlanta, said
that requests for outreach programs at senior centers have
increased recently. "As the population quietly admits that
because of Viagra and other reasons, they are sexually active,
senior (centers) are asking us to come out and talk to them
about it," Anderson said (Oliviero, Atlanta
Journal-Constitution, 11/10).

Rare infection a risk to gay, bisexual men in US-CDC

By Paul Simao ATLANTA (Reuters) - A rare sexually transmitted disease that is spreading among gay and bisexual men in Europe could be poised to surface in the United States, the U.S. Centers for Disease Control and Prevention said Thursday. The CDC, a federal agency that monitors epidemics and other health threats, urged doctors and clinics across the nation to be prepared to diagnose and treat gay and bisexual men infected with Lymphogranuloma venereum (LGV). It issued the advice after receiving reports of recent outbreaks in the Netherlands. The northern European nation has uncovered 92 cases of LGV dating back to 2003. It typically sees fewer than five cases per year. The infection is caused by specific strains of chlamydia, a sexually transmitted disease, and usually marked by genital ulcers, swollen lymph glands and flu-like symptoms. However most of the men recently infected in the Netherlands developed gastrointestinal bleeding, inflammation of the rectum and colon and other problems not often associated with the infection or other sexually transmitted diseases. Belgium, France, Sweden and Britain also have reported infections. It is not known whether America is seeing a similar surge because U.S. doctors are not required to report the infections to local health departments. "We expect it's a question of time before we see cases appearing here," said Dr. Stuart Berman, chief of the epidemiology and surveillance branch in the CDC's division of STD prevention. "This is an early warning." Although LGV can be cured by a three-week course of antibiotics, U.S. health officials could be hard pressed to keep a lid on the spread of the infection because it is uncommon in industrialized nations and easily misdiagnosed. Efforts to combat the disease also are complicated by the tendency of some gay and bisexual men to engage in high-risk sexual behavior. Dutch authorities found that a large number of the men recently infected with LGV had participated in sex parties and unprotected anal intercourse in the year before getting sick. Many also were infected with HIV, the virus that causes AIDS. REUTERS

Chicago Tribune Examines 'Growing Threat' of HIV/AIDS Among
Teenage Girls


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DR_ID=25598

The Chicago Tribune on Tuesday examined the "growing threat" of
HIV/AIDS among young women in the United States. According to a
recent federal study, 64% of new HIV cases between 1999 and 2002
occurred among women, the majority of whom were girls ages 13 to
19, the Tribune reports. "Young people aren't getting the right
messages and they suffer from the myth of invulnerability, very
prevalent among 14- to 19-year-olds," Lisa Henry-Reid, chair of
the division of adolescent and young adult medicine at Stroger
Hospital in Chicago, said. In addition, many teenage girls
"cannot negotiate safe sexual practices" because they are in
relationships with older men or do not have high self-esteem,
according to the Tribune. Teenagers also may not be getting
adequate sexual education from parents or in schools, the
Tribune reports. A 2003 Kaiser Family Foundation study of
adolescents and young adults showed that one in four young
people contract a sexually transmitted disease annually. The
study also found that 70% of women ages 15 to 24 consider forms
of contraception other than condoms -- such as birth control
pills -- to be "safer sex," and 80% consider oral sex "safer"
than vaginal or anal intercourse. According to Cynthia Tucker,
director of prevention at the Chicago Women's AIDS Project, "the
community doesn't know how to deal with the problem of HIV." In
addition, most sexual education is "about abstinence and leaves
[teenagers] ignorant of what the real threat is," Staci Bush, a
physicians' assistant at Howard Brown Health Center in Chicago,
said. "This is just a different generation. They're more
sexually active but ignorant," Bush added. As a result,
HIV-positive young women "feel isolated, fear disclosure and
stigmatization, and remain silent about their status," according
to the Tribune (Lauerman, Chicago Tribune, 9/1).

NEWS: [AIDS FRAUD] FDA Warns about Viralsol (in Adobe PDF format) which will be downloaded to your computer for viewing.

FDA Warning